19 Therefore, we conducted a systematic review and meta-analysis in the present study to better define the prognostic value of various miRNAs in patients with CADs. 16, 17 During a study of the relationship between CADs and miRNAs, we found severe errors in a previous meta-analysis. 8, 12, 13, 16, 17, 18 Of these, many researchers have suggested that miRNA or miRNA signatures may be diagnostic and prognostic biomarkers for human diseases. 13, 14, 15, 16, 17 As the importance of miRNAs increases more and more, new strategies based on miRNAs such as diagnostic and therapeutic targets have been developed. Recent research has reported that some miRNAs are associated with various diseases, including cancers, diabetes, and heart diseases. 8, 10 Furthermore, recent studies have suggested that levels of circulating miRNAs from vessel walls and inflammatory cells might be potential biomarkers of cardiovascular diseases. 8, 9 MiRNAs are involved in various biological and physiological processes. MicroRNAs (miRNAs) are small (approximately 20 nucleotide) noncoding RNAs, that can dysregulate protein translation by targeting messenger RNA. 1, 2, 3, 4, 5, 6, 7 Hence, to predict the survival rate from cardiovascular diseases, identifying novel prognostic markers is required, it would contribute to selecting better treatment options and reducing mortality. 1, 2, 3, 4, 5, 6 Although tremendous investment has revealed the pathogenesis of cardiovascular diseases, deaths from cardiovascular diseases are still increasing. Cardiovascular disease, including coronary artery diseases (CADs) is the one of the leading causes of death and illness in the developed world.
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